Program

Monday, June 26, 2017

09:00-10:30

DXA & QCT - New Developments

Chair: Harry Genant
Co-Chair: Andrew Burghardt
13+5
Feasibility study of quality control methodology for TBS
Presenter: Franck Michelet
Authors: Franck Michelet, Diane Krueger, Neil Binkley

13+5
Volumetric bone segmentation method for comparative bone structural analysis
Presenter: Jérôme Thevenot
Authors: Jérôme Thevenot, Jukka Hirvasniemi, Simo Saarakkala

13+5
Cortical measurements in QCT: still challenging despite progress
Presenter: Oleg Museyko
Authors: Oleg Museyko, Andreas Friedberger, Klaus Engelke

13+5
Automatic segmentation of the spine in CT Images using a highly generalisable deep-learning based framework
Presenter: Anjany Sekuboyina
Authors: Anjany Sekuboyina, Jan Kukačka, Jan S. Kirschke, Bjoern H. Menze, Alexander Valentinitsch

13+5
Innovative QCT to differentiate newly formed bone from resorbable calcium sulfate/phosphate implant material injected locally into osteoporotic proximal femurs
Presenter: Klaus Engelke
Authors: Klaus Engelke, Oleg Museyko, James Howe, Dominique Favell, Ronald Hill, Harry Genant


11:00-12:30

QUS - New Developments

Chair: Marie Müller & Guillaume Renaud

13+5
Cortical thickness and porosity assessment on ex vivo radius with axial transmission
Presenter: Jean-Gabriel Minonzio
Authors: Quentin Vallet, Jean-Gabriel Minonzio, Nicolas Bochud, Yohann Bala, Hélène Follet, Pascal Laugier

13+5
Ex-vivo validation of the osteporosis score for estimating bone mineral density through comparison with micro-CT measurements
Presenter: Marco Peccarisi
Authors: Marco Peccarisi, Tommaso De Marco, Francesco Conversano, Paola Pisani, Ernesto Casciaro, Antonio Greco, Roberto Franchini, Sergio Casciaro

13+5
Ex-vivo multiscale assessment of bone properties by ultrasound
Presenter: Quentin Grimal and Kay Raum
Authors: Quentin Grimal, Kay Raum

13+5
Fracture discrimination using ultrasound biomarkers of cortical bone
Presenter: Jean-Gabriel Minonzio
Authors: Jean-Gabriel Minonzio, Nicolas Bochud, Quentin Vallet, Adrien Etcheto, Karine Briot, Sami Kolta, Christian Roux, Pascal Laugier

13+5
High-frequency backscatter from cortical bone
Presenter: Kay Raum
Authors: Vantte Kilappa, Janos Hackenbeck, Gianluca Iori, Kay Raum


13:30-15:00

Poster Session I

Chair: Ralph Müller & Juan Du

P1
3D characterization of the morphology changes in the intervertebral disc and endplate during aging: A synchrotron CT study
Presenter: Hongbin Lu
Authors: Yong Cao, Nishuangfei Fei, Jianzhong Hu, Hongbin Lu

P2
A research of the correlation of nerve growth factor serum levels and osteoporotic fractures
Authors: Yupeng Liu, Dewei Zhao

P3
Assessing volumetric bone mineral density in adolescent idiopathic scoliosis: Quantitative computed tomography vs high-resolution peripheral quantitative computed tomography
Presenter: Elisa Man-Shan Tam
Authors: Elisa Man-Shan Tam, Fiona WP Yu, Vivian WY Hung, Lin Shi, Ling Qin, Bobby KW Ng, Winnie CW Chu, James Griffith, Jack CY Cheng, Tsz Ping Lam

P4
Assessment of cortical bone in hemodialysis patients using ultrasound - Evaluation of the usefulness of cortical QUS
Presenter: Ryoichi Suetoshi
Authors: Ryoichi Suetoshi, Takayuki Hamano, Isao Matsui, Satoshi Mikami, Yasue Obi

P5
Dependence of cortical bone anisotropic elasticity on anatomical location
Presenter: Xiran Cai
Authors: Laura Peralta, Xiran Cai, Pascal Laugier, Kay Raum, Quentin Grimal

P6
Femoral neck cortical bone stiffness measured by resonant ultrasound spectroscopy correlates strongly with its density.
Presenter: Quentin Grimal
Authors: Oliver R Boughton, Xiran Cai, Laura Peralta, Shaocheng Ma, Ulrich Hansen, Richard Abel, Pascal Laugier, Justin P Cobb, Quentin Grimal

P7
Long bone fatigue evaluation using coded nonlinear ultrasonic guided wave
Presenter: Xu Feng
Authors: Feng Xu, Dan Liu, Chengcheng Liu, Lawrence H. Le, Dean Ta

P8
Non-ionized microwave radiation on decalcified bone samples: instigating correlative bone analysis
Presenter: Thaqif El Khassawna
Authors: Thaqif El Khassawna, Diaa Eldin S. Daghma, Deeksha Malhan, Christian Heiss

P9
Protocols for serial block-face scanning electron microscopy of bone tissue
Presenter: Patricia Goggin
Authors: Patricia Goggin, Elaine Ho, Richard O C Oreffo, Philipp Schneider

P10
Toward measuring elastic properties of small animal cortical bone using resonant ultrasound spectroscopy: An aluminium phantom study
Presenter: XU Kailiang
Authors: Kailiang Xu, Pascal Dargent, Pascal Laugier, Quentin Grimal


15:00-15:30

K1 – Past, presence and future of quantitative bone ultrasound

Speaker: Pascal Laugier


15:30-17:00

High-Resolution In-Vivo Imaging I

Chair: Georg Schett & Gianluca Iori

13+5
Differing patterns of age-related bone loss between Chinese men and women: A population-based HR-pQCT study
Presenter: Tracy Y. Zhu
Authors: Tracy Y Zhu, Vivian WY Hung, Carol WY Choy, Carol KL Cheng, Jack CY Cheng, Ling Qin

13+5
Constructing age-specific reference curves for volumetric BMD and bone microarchitecture from HR-pQCT: The normal reference study
Presenter: Tracy Y. Zhu
Authors: Tracy Y Zhu, Vivian WY Hung, Carol WY Choy, Carol KL Cheng, Jack CY Cheng, Ling Qin

13+5
Lower trabecular density determines estimated bone strength in radial HR-pQCT measurements in rheumatoid arthritis patients – preliminary results
Presenter: Arnd Kleyer
Authors: Fabian Stemmer, Anna-Maria Liphardt, David Simon, Juergen Rech, Axel Hueber, Georg Schett, Klaus Engelke, Arnd Kleyer

13+5
Microarchitectural deterioration in patients with chronic kidney disease
Presenter: Ali Ghasem-Zadeh
Authors: Ali Ghasem-Zadeh, Rizwan Jaipurwala, Peter Mount,Xiaofang Wang, Leniod Churilov, Sandra Iuliano, Roger Zebaze, Cherie Chiang, Ego Seeman

13+5
The common region of interest between fixed offset and relative offset protocols in high-resolution peripheral quantitative computed tomography
Presenter: Ka-Yee Cheuk
Authors: Ka-Yee Cheuk, Elisa Man-Shan Tam, Fiona Wai-Ping Yu, Xiaofang Wang, Vivian Wing-Yin Hung, Wayne Yuk-Wai Lee, Ali Ghasem-Zahed, Roger Zebaze, Ego Seeman, Jack Chun-Yiu Cheng, Tsz Ping Lam


17:30-19:00

FEA & Bone Strength

Chair: Philippe Zysset & Graeme Campbell

13+5
A fast homogenized finite element approach for distal radius strength calculations from HRpQCT images
Presenter: Bert van Rietbergen
Authors: Andrés Julián Arias-Moreno, Hadi S. Hosseini, Keita Ito, Philippe K. Zysset, Bert van Rietbergen

13+5
Cortical bone histomorphometry of the human femoral shaft: relations with hip strength
Presenter: Gianluca Iori
Authors: Gianluca Iori, Andreas Reisinger, Laura Peralta, Melanie Gräsel, Reinhard Barkman, Dieter Pahr, Kay Raum

13+5
QCT-based finite element estimation of hip strength: Role of anisotropy
Presenter: Philippe Zysset
Authors: Jarunan Panyasantisuk, Ghislain Maquer, Enrico Dall’Ara, Dieter Pahr, Philippe Zysset

13+5
The relationship between advanced glycation endproducts and local bone mechanics using fluorescence microscopy and reference point indentation
Presenter: Graeme Campbell
Authors: Graeme M. Campbell, Felix N. Schmidt, Michael M. Morlock, Björn Busse

13+5
Effects of subject-specific geometry, bone density and loading conditions on the strains at the femur neck
Presenter: Zahra Asgharpour
Authors: Pim Pellikaan, Zahra Asgharpour, Ilse Jonkers, G. Harry van Lenthe, Jos Vander Sloten

Tuesday, June 27, 2017

09:00-10:30

Opportunistic Screening

Chair: John Shepherd
Co-Chair: Klaus Engelke
13+5
Automatic no-dose analysis of bone mineral density in an incidental screening scenario
Presenter: Wolfram Timm
Authors: Wolfram Timm, J. Keenan Brown, Claus C. Glüer, Reimer Andresen

13+5
Discrepancies between synchronous and asynchronous phantom based BMD calibration in QCT
Presenter: Oleg Museyko
Authors: Oleg Museyko, S. Holz, P. Dankerl, M. Uder, Klaus Engelke

13+5
Opportunistic fracture risk estimation based on multi-detector CT images of the spine via local classification of textures
Presenter: Alexander Valentinitsch
Authors: Alexander Valentinitsch, Stefano Trebeschi, Johannes Kaesmacher, Thomas Baum, Jan S. Kirschke

13+5
Opportunistic identification of osteoporotic vertebral fractures with computed tomography: clinical practice compared to a semi-automatic computer-assisted diagnosis system
Presenter: Eleni Kariki
Authors: Eleni P. Kariki, Paul A. Bromiley, Timothy F. Cootes, Judith E. Adams

13+5
Validation of asynchronous quantitative bone densitometry of spine: Accuracy, short-term reproducibility, and a comparison with conventional quantitative computed tomography
Presenter: Ling Wang
Authors: Ling Wang, Xiaoguang Cheng, Yongbin Su, Qianqian Wang


09:00-10:30

US - Guided Waves

Chair: Mami Matsukawa & Xiran Cai

13+5
Application of dispersive Radon transform to process ultrasonic guided waves signals in long cortical bone
Presenter: Kailiang Xu
Authors: Kailiang Xu, Pascal Laugier, Jean-Gabriel Minonzio

13+5
Assessment of cortical thickness and elasticity using ultrasonic axial transmission
Presenter: Jean-Gabriel Minonzio
Authors: Nicolas Bochud, Quentin Vallet, Xiran Cai, Quentin Grimal, Jean-Gabriel Minonzio, Pascal Laugier

13+5
Cortical thickness and porosity assessment on ex-vivo tibia with axial transmission
Presenter: Johannes Schneider
Authors: Johannes Schneider, Donatien Ramiandriosa, Gianluca Iori, Melanie Gräsel, Reinhard Barkmann, Kay Raum, Pascal Laugier, Jean-Gabriel Minonzio

13+5
Low-cost Lamb wave characterization technique using one transmitter and two receivers: An experimental study
Presenter: Shigeaki Okumura
Authors: Shigeaki Okumura, Vu-Hieu Nguyen, Hirofumi Taki, Toru Sato

13+5
Suitability of low-frequency axial transmission acoustics as a screening method for bone mass density-defined osteoporosis
Presenter: Florian Vogl
Authors: Florian Vogl, Bernd Friesenbichler, Hans Gerber, William R. Taylor, Inés Anne Kramers-de Quervain


11:00-12:30

Future US Cortical Bone Biomarkers

Chair: Reinhard Barkmann & Florian Vogl

13+5
A new QUS approach for measuring cortical porosity and other bone properties relevant for discriminating patients with different mineralization statuses
Presenter: Melanie Gräsel
Authors: Melanie Gräsel, Claus C. Glüer, Reinhard Barkmann

13+5
Characterization of cortical bone using multiple scattering of ultrasound
Presenter: Marie Muller
Authors: Yasamin Karbalaeisadegh, Omid Yousefian, Gianluca Iori, Kay Raum, Marie Muller

13+5
Estimation of cortical bone porosity by applying traditional and multivariate analysis on ultrasound pulse-echo signals – a FDTD study
Presenter: Markus Malo
Authors: Satu Inkinen, Juha Töyräs, Jukka Jurvelin, Markus Malo

13+5
Imaging of cortical pores using ultrasound contrast agents: A phantom study
Presenter: Juan Du
Authors: Juan Du, Melanie Gräsel, Reinhard Barkmann, Kay Raum

13+5
Ultrasound imaging of cortical bone at the distal radius
Presenter: Guillaume Renaud
Authors: Guillaume Renaud, Pieter Kruizinga, Pascal Laugier


11:00-12:30

Fractures & Implants

Chair: Bert v. Rietbergen & Timo Damm

13+5
Effect of preparation method and bone mineral density on bone-interface densification in hip arthroplasty
Presenter: Johanna Bätz
Authors: Johanna Bätz, Philipp Messer, Frank Lampe, Klaus Püschel, Anke Klein, Michael M. Morlock, Graeme M. Campbell

13+5
Effect of semi-automatic contouring on short-term reproducibility of bone parameters obtained from HRpQCT measurements of distal radius fractures
Presenter: Frans Heyer
Authors: Frans Heyer, Jacobus de Jong, Martijn Poeze, Paul Willems, Piet Geusens, Bert van Rietbergen, Joop van den Bergh

13+5
Fabrication of oriented hydroxyapatite film by RF magnetron sputtering
Presenter: Takafumi Kubota
Authors: Takafumi Kubota, Keshiro Hirata, Kazuma Mori, Shohei Tokuda, Daisuke Koyama, Mami Matsukawa

13+5
Quantitative assessment of radial bone structural distribution in the proximity of degradable implants by micro-computed tomography
Presenter: Timo Damm
Authors: Timo Damm, H. Naujokat, J. Wiltfang, Claus C. Glüer

13+5
Spatial assessment of bone microarchitecture in postmenopausal women with a recent Colles’ fracture
Presenter: Andrew Burghardt
Authors: Andrew J. Burghardt, James M Peterson, Sundeep Khosla, Julio Carballido-Gamio


13:30-15:00

Poster Session II

Chair: Philip Schneider & Marco Peccarisi

P1
Bone densitometry in patients with acromegaly may be misleadingly normal while vertebral fractures are prevalent yet often remain occult
Presenter: Marko Stojanovic
Authors: Marko Stojanovic, Dragana Miljic, Sandra Pekic, Mirjana Doknic, Marina Nikolic Djurovic, Zvezdana Jemuovic, Vera Popovic, Milan Petakov

P2
Estimation of piezoelectric sensitivity at an ultrasound frequency in bovine cancellous bone
Presenter: Atsushi Hosokawa
Authors: Atsushi Hosokawa

P3
Explorative study of rats femorale bone with experimentally induced diabetes by resonant ultrasound spectroscopy
Presenter: Paulina Hernández
Authors: Paulina Alicia Irais Hernández-Becerra, Miguel Vargas-Luna, María Raquel Huerta-Franco, Isabel Delgadillo-Holtfort, Gabriel Herrera-Pérez, Rafael Vargas-Bernal, Xóchitl Sofía Ramírez-Gómez, Esmeralda Rodríguez-Miranda

P4
Fabrication of a self- assembling poly γ-glutamic acid based nanoparticle loaded triptolide for the treatment of rheumatoid arthritis
Presenter: Zhang Li
Authors: Zhang Li, Junli Chang, Yongjian Zhao, Hao Xu, Tengteng Wang, Qiang Li, Yongjun Wang, Qianqian Liang

P5
Microstructural decay in spinal cord injury
Presenter: Ali Ghasem-Zadeh
Authors: Ali Ghasem-Zadeh, Roger Zebaze, Andrew Nunn, Maya Panisset, Xiao-Fang Wang, Mary P. Galea, Ego Seeman

P6
Prevalence of sarcopenia in community dwelling German males and females 70+ using different recognized definitions. A BIA based approach
Presenter: Wolfgang Kemmler
Authors: Wolfgang Kemmler, Simon von Stengel, Klaus Engelke

P7
Sexual dimorphism in cortical bone morphology during pubertal growth in Chinese adolescents
Presenter: Elisa Man-Shan Tam
Authors: Ka-Yee Cheuk, Xiaofang Wang, Fiona Wai-Ping Yu, Elisa Man-Shan Tam, Bobby Kin-Wah Ng, Tsz Ping Lam, Ali Ghasem-Zahed, Roger Zebaze, Ego Seeman, Jack Chun-Yiu Cheng

P8
Skeletal site and location dependent elastic properties of human cortical bone measured by resonant ultrasound spectroscopy
Presenter: Xiran Cai
Authors: Xiran Cai, Laura Peralta, Quentin Vallet, Nicolas Bochud, Oliver Boughton, Richard Abel, Justin Cobb, Kay Raum, Jean-Gabriel Minonzio, Pascal Laugier, Quentin Grimal

P9
Ultrasonic computed tomography based on full-waveform inversion for bone quantitative imaging
Presenter: Simon Bernard
Authors: Simon Bernard, Vadim Monteiller, Dimitri Komatitsch, Philippe Lasaygues

P10
Ultrasonically induced electrical potentials in bovine cortical bone
Presenter: Taiki Makino
Authors: Taiki Makino, Koki Takano, Takafumi Kubota, Sayaka Matsukawa, Shinji Takayanagi, Takahiko Yanagitani, Mami Matsukawa


15:00-15:30

K2 – Impact of deep learning and big data analysis in MSK radiology

Speaker: John Shepherd


15:30-17:00

Clinical Applications I

Chair: Jean-Denis Laredo

13+5
Estimation of fracture risk based on the concept of the muscle bone unit
Presenter: Rainer Rawer
Authors: Rainer Rawer, Johannes Willnecker

13+5
Optical body shape phenotypes using statistical shape modeling for predicting osteopenia, sarcopenia, and obesity status in women
Presenter: John Shepherd
Authors: John Shepherd, M. Sommer, Ey. Liu, B. Fan, B. Ng, J. Mastick, C. Miaskowski

13+5
Personalised bone health prognosis through integrated patient big data analysis of medical images, molecular profiles and physical activity levels
Presenter: Nicholas Ohs
Authors: Nicholas Ohs, Jan Kleffmann, Yuk-Wai Wayne Lee, Chun-Yiu Jack Cheng, Peter Arbenz, Ralph Müller, Patrik Christen

13+5
Unique correlation pattern between cortical and trabecular bone qualities and standard dynamometer handgrip strength in girls with adolescent idiopathic scoliosis
Presenter: Elisa Tam
Authors: Elisa MS Tam, Ka Yee Cheuk, Vivian WY Hung, Fiona WP Yu, Bobby KW Ng, X Edward Guo, Jack CY Cheng, Tsz Ping Lam

13+5
Whole body vibration therapy reduces local peak loading in the distal tibia of girls with adolescent idiopathic scoliosis
Presenter: Gianna Marano
Authors: Gianna Marano, Yuk-Wai Wayne Lee, Tsz-Ping Lam, Ralph Müller, Patrik Christen


17:30-19:00

Advanced Microscopy & Tomography

Chair: Ling Qin & Duncan Betts

13+5
Assessment of the lacuno-canalicular network in human bone from magnified phase nano-CT images
Presenter: Boliang Yu
Authors: Boliang Yu, Max Langer, Alexandra Pacureanu, Cécile Olivier, Pierre-Jean Gouttenoire, Peter Cloetens, Françoise Peyrin

13+5
Nano-imaging of bone mineral using qsSAXSI: a contribution to specifying bone quality
Presenter: Aurelien Gourrier
Authors: Aurelien Gourrier, Mariana Verezhak, Helene Follet, Delphine Farlay

13+5
Osteocyte lacuna segmentation from ultra-high resolution desktop micro-CT images: Low precision reveals limitation of state of the art
Presenter: Duncan Betts
Authors: Duncan C Betts, Elliott Goff, Michele Casanova, Zihui Li, Patrik Christen, Ralph Müller

13+5
Prevalence of trabecular microcalli in human vertebrae increases with alendronate treatment
Presenter: Annika vom Scheidt
Authors: Annika vom Scheidt, Michael Amling, Klaus Püschel, Björn Busse

13+5
Three-dimensional imaging of crack path and osteonal microstucture in human cortical bone on three paired anatomical locations
Presenter: Rémy Gauthier
Authors: Rémy Gauthier, Max Langer, Hélène Follet, Cécile Olivier, Frédéric Rongiéras, David Mitton, Françoise Peyrin

13+5
Extending Synchrotron X-ray Microscopy to the Laboratory_X-Ray Microscopy as a correlative imaging technique
Presenter: Mohsen Samadi
Authors: Mohsen Samadi

Wednesday, June 28, 2017

09:00-10:30

Small Animal Imaging

Chair: Sharmila Majumdar
Co-Chair: Christine Chappard
13+5
3D digital anatomic angioarchitecture of the mouse spinal cord: A synchrotron radiation micro-CT study
Presenter: Hongbin Lu
Authors: Hongbin Lu, Yong Cao, Nishuangfei Fei, Jianzhong Hu

13+5
In-vivo tracking of individual cortical bone remodeling events in a rabbit model
Presenter: Arash Panahifar
Authors: Arash Panahifar, Kimberly Harrison, David M.L. Cooper

13+5
Therapeutic effects of low-intensity pulsed ultrasound with different intensities on osteoporosis in OVX rats
Presenter: Shuxin Sun
Authors: Shuxin Sun, Lijun Sun, Liang Tang, Yiting Kang, Tingting Zhao, Tao Zhou, Dean Ta

13+5
Using active ahape models to quantify impeded skeletal development in an early-onset rat model of type 2 diabetes mellitus
Presenter: Graeme Campbell
Authors: Graeme M. Campbell, Ann-Kristin Picke, Christine Hofbauer, Björn Busse, Lorenz C. Hofbauer, Michael M. Morlock

13+5
Visualization and pathological characteristics of cartilage and subchondral bone change in lumbar facet joint OVX mouse model using PPCT imaging
Presenter: Hongbin Lu
Authors: Jian-Zhong Hu, Yong Cao, Hongbin Lu


11:00-12:30

Cell & Molecular Imaging

Chair: Claus Glüer
Co-Chair: Tobias Bäuerle
13+5
Assessment of bone marrow metabolism by FDG PET allows early detection of experimental osteolytic bone metastasis
Presenter: Stephan Ellmann
Authors: Stephan Ellmann, Lisa Seyler, Jochen Evers, Henrik Heinen, Michael Uder, Tobias Bäuerle

13+5
Dual energy synchrotron X-ray imaging of bone-seeking tracer elements
Presenter: Arash Panahifar
Authors: Arash Panahifar, Nazanin Samadi, L. Dean Chapman, David M.L. Cooper

13+5
IL-20R1, IL-22R1 and bone quality: new therapeutical targets against bone fragility and osteoporosis
Presenter: Julia Triebus
Authors: Julia Triebus, Gianluca Iori, Johannes Schneider, Kay Raum, Robert Sabat

13+5
Material science meets biology: Study of the 3D structural and mechanical environment of cells regulating modeling in bones without osteocytes
Presenter: Lior Ofer
Authors: Lior Ofer, Elazar Zelzer, Paul Zaslansky, Ron Shahar

13+5
Receptor-specific imaging in experimental breast cancer bone metastasis by MRI and PET using a signal amplification strategy
Presenter: Tobias Bäuerle
Authors: Alexei Bogdanov, Suresh Gupta, Aurora Rodríguez-Rodríguez, Peter Caravan, Zheng Shaokuan, Tobias Bäuerle


13:30-15:00

High-Resolution In-Vivo Imaging II

Chair: Steven Boyd & Frans Heyer

13+5
BMD and structural analysis of CT-images of OA knees comparing subchondral bone under meniscus and not under meniscus
Presenter: Frederike Sannmann
Authors: Frederike Sannmann, Christine Chappard, Jean-Denis Laredo, Klaus Engelke

13+5
BMD-calibrated measurements of local porosity in human femoral cortical bone
Presenter: Gianluca Iori
Authors: Gianluca Iori, Vantte Kilappa, Frans Heyer, Caroline Wyers, Peter Varga, Johannes Schneider, Joop van den Bergh, Kay Raum

13+5
Human knee bone microarchitecture six years post anterior cruciate ligament reconstructive surgery as assessed by HR-pQCT
Presenter: Steven Boyd
Authors: Andres Kroker, Sarah Manske, Ying Zhu, Rhamona Barber, Nicholas Mohtadi, Steven Boyd

13+5
Optimising the quantification of bone microstructure in the human calcaneus using HR-pQCT
Presenter: Louis Metcalf
Authors: Louis M. Metcalf, Jenna A. Fogden, Rhea H. Patel, Margaret A. Paggiosi, Graham J. Kemp, Eugene V. McCloskey

13+5
Three-dimensional mapping of the joint space for knee osteoarthritis based on high-resolution computed tomography: A multiscale analysis
Presenter: Christine Chappard
Authors: Houda Mezlini-Gharsallah, Rabaa Youssef, Jean denis Laredo, Christine Chappard

Thursday, June 29, 2017

09:00-10:30

Numerical US Simulation Models

Chair: Dean Ta & Melanie Gräsel

13+5
A real-size FDTD simulation of ultrasound propagation inside human radius
Presenter: Yoshiki Nagatani
Authors: Yoshiki Nagatani, Isao Mano, Mami Matsukawa, Koki Takano, Ko Chiba

13+5
Bone repair and ultrasound stimulation : a multiscale computational study
Presenter: Cécile Baron
Authors: Cécile Baron, Carine Guivier-Curien, Vu-Hieu Nguyen, Salah Naili

13+5
Influence of trabecular microstructure on the simulation of ultrasound through the skull
Presenter: James Robertson
Authors: James L.B. Robertson, Jillian E. Urban, Joel D. Stitzel, Ben T. Cox, Bradley E. Treeby

13+5
Physical and mathematical modeling of guided waves propagation in cortical bone in presence of soft tissues
Presenter: Alexey Tatarinov
Authors: Alexey Tatarinov, Arcady Soloviev, Vladimir Panov

13+5
Simulation study on axial ultrasound propagation in cortical bone model–effects of shape and heterogeneity–
Presenter: Koki Takano
Authors: Koki Takano, Yoshiki Nagatani, Mami Matsukawa


09:00-10:30

Bone & Soft Tissue

Chair: James Griffith & Andreas Friedberger

13+5
Integrating dual energy X-Ray and 3D surface imaging for enhanced multicompartment tissue composition assessment: the Ultra DXA project
Presenter: Bennett Ng
Authors: Bennett K. Ng, Wei Wang, Chao Huang, Howard Weiss, Thomas L. Kelly, Kevin E. Wilson, John A. Shepherd

13+5
Magnetic Resonance Imaging (MRI) and Spectroscopy (MRS) methods for quantitative evaluation of intramuscular adipose tissue (IMAT)
Presenter: Alexandra Grimm
Authors: Alexandra Grimm, Heiko Meyer, Mathias Nittka, Esther Raithel, Oliver Chaudry, Andreas Friedberger, Michael Uder, Wolfgang Kemmler, Harald H. Quick, Klaus Engelke

13+5
Predicting body composition from forearm and lateral distal femur hologic bone densitometry scans
Presenter: Bo Fan
Authors: Bo Fan, Bennett Ng, Natasha Din, Leila Kazemi, Babette Zemel, Heidi Kalkwarf, Andrea Kelly, James Heubi, Kimberly Yolton, Amir Pasha Mahmoudzadeh, John Shepherd

13+5
Quantification of muscle fat fraction from a combined analysis of T1 weighted and dixon MRI images of the thigh
Presenter: Oliver Chaudry
Authors: Oliver Chaudry, Andreas Friedberger, Alexandra Grimm, Marc Teschler, Oleg Museyko, Wolfgang Kemmler, Klaus Engelke

13+5
Random forest based segmentation of hand muscle in MRI
Presenter: Andreas Friedberger
Authors: Andreas Friedberger, Camille Figueiredo, Oleg Museyko, Alexandra Grimm, Isabelle d'Oliveira, Tobias Bäuerle, Jürgen Rech, Oliver Chaudry, Michael Uder, Georg Schett, Klaus Engelke


11:00-12:30

US - Propagation Models

Chair: Quentin Grimal & Yoshiki Nagatani

13+5
The relationship between ultrasonic backscatter propagation properties and cancellous bone microstructural variations
Presenter: Xingxing Chou
Authors: Xingxing Chou, Feng Xu, Ying Li, Chengcheng Liu, Dean Ta

13+5
Contrast resolution enhancement in ultrasonic computed tomography of bones by way of a wavelet-based coded excitation method
Presenter: Philippe Lasaygues
Authors: Philippe Lasaygues, Khaled Metwally, Cecile Baron, Samantha Fernandez, Laure Balasse

13+5
Studying the effect of porosity and pore size in cortical bone on ultrasonic parameters
Presenter: Marie Muller
Authors: Omid Yousefian, Yasamin Karbalaeisadegh, Gianluca Iori, Kay Raum, Marie Muller

13+5
Ultrasonic backscatter characterization of cancellous bone using Nakagami model
Presenter: Chengcheng Liu
Authors: Chengcheng Liu, Boyi Li, Ying Li, Feng Xu, Dean Ta, Weiqi Wang


11:00-12:30

Bone Structure & Texture

Chair: Francoise Peyrin & Tracy Y. Zhu

13+5
A Multiscale analysis of tibial subchondral bone micro-architecture based on cone beam computed tomography
Presenter: Christine Chappard
Authors: Gaelle Mitton, Hamid Bouhadoun, Eliza Budyn, Klaus Engelke, Jean Denis Laredo,  Christine Chappard

13+5
Fractal texture phantom for TBS calibration
Presenter: Franck Michelet
Authors: Franck Michelet, Christophe Lelong

13+5
Quantification of bone microstructure using cone-beam computed tomography
Presenter: Karen Mys
Authors: Karen Mys, Filip Stockmans, Evie Vereecke, G. Harry van Lenthe

13+5
Quantitative comparison of different micro CT based trabecular bone image analysis software tools
Presenter: Dieter Pahr
Authors: Dieter Pahr, Lukas Steiner

13+5
Relationships between cortical bone microstructure and the effective mesoscopic elasticity
Presenter: Xiran Cai
Authors: Xiran Cai, Renald Brenner, Laura Peralta, Cécile Olivier, Pierre-Jean Gouttenoire, Françoise Peyrin, Pascal Laugier, Quentin Grimal


15:00-15:30

K3 – Fancy ways of looking at muscle

Speaker: James Griffith


15:30-17:00

Clinical Applications II

Chair: Valerie Bousson & Alexander Valentinitsch

13+5
Calcium plus Vit-D for adolescent idiopathic scoliosis: A randomized double-blinded placebo-controlled trial using HR-pQCT and FEA
Presenter: Elisa Man Shan Tam
Authors: Tsz Ping Lam, Benjamin Hon-kei Yip, Ka-yee Cheuk,Elisa Man-shan Tam,Wayne Yuk-wai Lee, Kwong-man Lee, Fiona Wai-ping Yu, Alec Lik-hang Hung, Bobby Kin-wah Ng, Jack Chun-yiu Cheng

13+5
Osteoporotic fracture in elderly Chinese men and women: A comparison of vertebral-cortex-fracture based and vertebral-deformity based methods
Presenter: James F. Griffith
Authors: Min Deng, James Griffith, Jason Leung, Anthony Kwok, Timothy Kwok,Ping Chung Leung

13+5
Persistent Low Bone Mass(LBM) at Maturity in Adolescent Idiopathic Scoliosis(AIS) Patients – A 4-year Longitudinal Follow-up Study
Presenter: Vivian Wing Yin Hung
Authors: YU Wai Ping Fiona, HUNG Vivian Wing Yin, YIP Benjamin Hon Kei, QIN Ling, LAM Tsz Ping,CHENG Jack Chun Yiu

13+5
Short-term monitoring of Denosumab treatment effectiveness on BMD recovery in breast cancer patients assessed through the echosound approach
Presenter: Paola Pisani
Authors: Paola Pisani, Maurizio Muratore, Francesco Conversano, Marco Di Paola, Rosachiara Forcignanò, Mariangela Ciccarese, Giammarco Surico, Laura Quarta, Eugenio Quarta, Richard Tarparelli, Sergio Casciaro

13+5
Thoracolumbar intervertebral disc area morphometry in elderly Chinese: radiographic quantifications at baseline and year-4 follow-up
Presenter: James F. Griffith
Authors: Jun-Qing Wang, Zoltán Káplár, Jason Leung, James F. Griffith, Ping Chung Leung, Yi-Xiang Wang


17:30-19:00

Measurement & Interpretation of Material Properties

Chair: Mary Bouxsein & Aurelien Gourrier

13+5
Determination of anisotropic elastic properties of cortical bone matrix using FFT-based inverse homogenization
Presenter: Xiran Cai
Authors: Xiran Cai, Laura Peralta, Renald Brenner, Pascal Laugier, Quentin Grimal

13+5
CT calibration for micro structural parameters on multi-site studies
Presenter: Felix Sebastian Leo Thomsen
Authors: Felix Sebastian Leo Thomsen, Claus C. Glüer, Claudio Augusto Delrieux

13+5
Evaluation of trabecular tissue stiffness in patients with atraumatic vertebral fractures
Presenter: Johannes Schneider
Authors: Johannes Schneider, Matthias Pumberger, Michael Putzier, Kay Raum

13+5
On the cortical bone elasticity, toughness and bone quality
Presenter: Xiran Cai
Authors: Xiran Cai, Rémy Gauthier, Laura Peralta, Hélène Follet, Evelyne Gineyts, Max Langer, Boliang Yu, Cécile Olivier, Françoise Peyrin, Pascal Laugier, David Mitton, Quentin Grimal

13+5
Trabecular tissue Young's modulus assessed from resonant ultrasound spectroscopy
Presenter: Quentin Grimal
Authors: Hassiba Daoui, Xiran Cai, Fouad Boubenider,Pascal Laugier, Quentin Grimal

Workshops

Monday, June 26, 2017 | 20:30 - 21:30

W1 DXA: Basic Concepts, Assumptions and Error Sources

Speaker: Kevin Wilson

DXA is by far the most widely used technique to measure bone mineral density. The two workshops will provide in depth informatiThe first workshop focusses on the basic concepts, assumptions and error sources of DXA such as: What is BMD really? What are some of the key assumptions made by commercially available DXA scanners? What errors are frequently seen in the published literature that utilizes DXA? Given these facts, why is DXA widely used clinically?
The target audience for the first lecture includes: the novice unfamiliar with DXA technique, the user who regards the DXA machine as a black box, and finally, those who just want to be able to critically read the peer-reviewed literature where DXA is employed in the research or pre-clinical setting.
We are happy that the two workshops will be given by two of the world leading experts in the field. Kevin Wilson, PhD heads DXA development at Hologic and has been instrumental in the implementation and innovation of DXA technology over the last 20 years. John Shepherd PhD is a professor in Radiology and Biomedical Imaging at the University of California San Francisco. He has also been in the field for over 20 years developing novel applications and biomarkers using DXA technology. He has contributed/chaired scientific committees on DXA standardization, in depth technical reports on DXA for the ICRU and IAEA, and drafted ISCD positions for clinical use of DXA. He has published over 170 peer reviewed articles in the field, a Fulbright scholar and the most recent past President of the ISCD.


Monday, June 26, 2017 | 20:30 - 21:30

W2 Creating FE Models from CT Data

Speaker: Dieter Pahr

Image based FEA modeling is a challenging task. Several key aspects like image processing, meshing, material mapping, and post-processing need to be considered. But also accompanying tasks, for example, data storage, creating workflows, scripting, and parameter studies are important in order to obtained validated FEA results efficiently. Within this workshop the software medtool (www.dr-pahr.at) will be used to show possibilities and solutions with respect to the above points. Applicants get access to the software as well as short examples for hand-ons.


Tuesday, June 27, 2017 | 20:30 - 21:30

W3 DXA: Advanced Applications

Speaker: John Shepherd

Today DXA is much more than BMD measurement of spine and hip. Advanced applications, the topics of the second workshop include the measurement of modeling of soft tissue and special regions like visceral and subcutaneous fat, special considerations for infants and children, finite element modeling, shape and appearance modeling, and even quantification of breast density. Thus, the second workshop is to fully understand the breadth of DXA capabilities for research.
We are happy that the two workshops will be given by two of the world leading experts in the field. Kevin Wilson, PhD heads DXA development at Hologic and has been instrumental in the implementation and innovation of DXA technology over the last 20 years. John Shepherd PhD is a professor in Radiology and Biomedical Imaging at the University of California San Francisco. He has also been in the field for over 20 years developing novel applications and biomarkers using DXA technology. He has contributed/chaired scientific committees on DXA standardization, in depth technical reports on DXA for the ICRU and IAEA, and drafted ISCD positions for clinical use of DXA. He has published over 170 peer reviewed articles in the field, a Fulbright scholar and the most recent past President of the ISCD.


Tuesday, June 27, 2017 | 20:30 - 21:30

W4 Small Animal Imaging Techniques

Speaker: Claus Glüer /Tobias Bäuerle

The workshop „Small animal imaging techniques“ will be moderated by Claus Glüer, PhD and Tobias Bäuerle, MD. The presenters will give an overview on multimodal techniques for small animal imaging including MRI, CT, PET, SPECT, ultrasound and optical imaging. Thereby, techniques and applications on musculoskeletal imaging will be explained and summarized with experience from the small animal imaging centers at the Universities Kiel and Erlangen, Germany.


Friday, June 30, 2017 | 09:00 - 10:30

W5 US Hands On Workshop: High-Frequency Ultrasound Backscatter I

Speaker: Marie Mueller

Single elements have been historically favored for the ultrasonic assessment of bone. However, the use of multiple elements array is starting to spread across multiple research groups of the community. The workshop will focus on using linear arrays connected to a multiple channel ultrasound scanner (Verasonics® Vantage, Verasonics, Seattle, WA), to record backscattered signals in the 4-7 MHz frequency range. We will show how to extract the incoherent contribution to the signals, and how, by exploiting multiple scattering, which occurs in this higher frequency range, some parameters of the micro-architecture can be retrieved. We will present examples on bone phantoms, and on real bovine bone.


Friday, June 30, 2017 | 09:00 - 10:30

W6 US Hands On Workshop: Guided Wave Signal Processing

Speaker: Jean-Gabriel Minonzio

Guided waves can be found in a variety of domains such as musical instruments, optical fibers or underwater acoustics. In these cases, waves are propagating in a bounded medium and thus, the different reflections or paths interacts to to create interference patterns leading to guided waves. Measurements of such waves together with appropriate waveguide modeling have therefore the potential for providing estimations of both geometric and elastic properties of the waveguide. This point of view is currently applied for in vivo cortical bone assessment, using axial transmission technique. In this configuration, ultrasonic transmitters and receivers are aligned with the bone axis.

The aims of the workshop is to provide insights into the following topics:

- axial transmission
- guided waves of the free plate model (Lamb modes)
- guided wave estimation using spatio-temporal Fourier transform and Radon transform
- enhancement of the guided wave estimation using singular value decomposition (SVD)
- guided wave fitting and waveguide parameter estimation
- soft tissue effect and in vivo measurement

The workshop will be illustrated with experimental examples.


Friday, June 30, 2017 | 11:00 - 12:30

W7 US Hands On Workshop: High-Frequency Ultrasound Backscatter II

Speaker: Kay Raum / Juan Du

Building up on the content of workshop W5, this workshop will demonstrate a medical ultrasound scanner (SonixTouch®, BK Ultrasound, Richmond, BC, Canada), to record backscattered signals from bone with custom transmit sequences and in the 2-10 MHz range. The following topics will be covered:
- overview of system architecture (hardware/software) including 128-channel data acquisition box
- software implementation of custom acquisition sequences (C++/Matlab)
- examples of backscatter measurements in bone
- examples of contrast enhanced measurements
- concepts of spectral data analysis (including validation by experiments/sound propagation simulations)
- live-demo measurements
Results measured on human bones will be presented.


Friday, June 30, 2017 | 11:00 - 12:30

W8 QCT - How Does It Really Work?

Speaker: Klaus Engelke

QCT is a 3D imaging technique to quantify BMD, geometry and is also the basis for FE analysis. This workshop will concentrate on specifics and limitations of QCT such as BMD calibration, influence of CT acquisition and reconstructions parameters on accuracy and precision of the impact of marrow fat. It will revisit the impact of segmentation and spatial resolution on cortical parameters such as thickness and porosity. It will briefly discuss dual energy options and will review and put in context approaches of opportunistic screening. This workshop will be interactive to reflect and discuss results presented during the conference. The potential QCT in OA and RA and in muscle imaging are advanced topics. The workshop will be given by Klaus Engelke, who has more than 25 years in Micro-CT and QCT technology and in musculoskeletal imaging processing.



Poster Session I - Monday, June 26, 2017

P1
3D characterization of the morphology changes in the intervertebral disc and endplate during aging: A synchrotron CT study
Presenter: Hongbin Lu
Authors: Yong Cao, Nishuangfei Fei, Jianzhong Hu, Hongbin Lu

P2
A research of the correlation of nerve growth factor serum levels and osteoporotic fractures
Authors: Yupeng Liu, Dewei Zhao

P3
Assessing volumetric bone mineral density in adolescent idiopathic scoliosis: Quantitative computed tomography vs high-resolution peripheral quantitative computed tomography
Presenter: Elisa Man-Shan Tam
Authors: Elisa Man-Shan Tam, Fiona WP Yu, Vivian WY Hung, Lin Shi, Ling Qin, Bobby KW Ng, Winnie CW Chu, James Griffith, Jack CY Cheng, Tsz Ping Lam

P4
Assessment of cortical bone in hemodialysis patients using ultrasound - Evaluation of the usefulness of cortical QUS
Presenter: Ryoichi Suetoshi
Authors: Ryoichi Suetoshi, Takayuki Hamano, Isao Matsui, Satoshi Mikami, Yasue Obi

P5
Dependence of cortical bone anisotropic elasticity on anatomical location
Presenter: Xiran Cai
Authors: Laura Peralta, Xiran Cai, Pascal Laugier, Kay Raum, Quentin Grimal

P6
Femoral neck cortical bone stiffness measured by resonant ultrasound spectroscopy correlates strongly with its density.
Presenter: Quentin Grimal
Authors: Oliver R Boughton, Xiran Cai, Laura Peralta, Shaocheng Ma, Ulrich Hansen, Richard Abel, Pascal Laugier, Justin P Cobb, Quentin Grimal

P7
Long bone fatigue evaluation using coded nonlinear ultrasonic guided wave
Presenter: Xu Feng
Authors: Feng Xu, Dan Liu, Chengcheng Liu, Lawrence H. Le, Dean Ta

P8
Non-ionized microwave radiation on decalcified bone samples: instigating correlative bone analysis
Presenter: Thaqif El Khassawna
Authors: Thaqif El Khassawna, Diaa Eldin S. Daghma, Deeksha Malhan, Christian Heiss

P9
Protocols for serial block-face scanning electron microscopy of bone tissue
Presenter: Patricia Goggin
Authors: Patricia Goggin, Elaine Ho, Richard O C Oreffo, Philipp Schneider

P10
Toward measuring elastic properties of small animal cortical bone using resonant ultrasound spectroscopy: An aluminium phantom study
Presenter: XU Kailiang
Authors: Kailiang Xu, Pascal Dargent, Pascal Laugier, Quentin Grimal


Poster Session II - Tuesday, June 27, 2017

P1
Bone densitometry in patients with acromegaly may be misleadingly normal while vertebral fractures are prevalent yet often remain occult
Presenter: Marko Stojanovic
Authors: Marko Stojanovic, Dragana Miljic, Sandra Pekic, Mirjana Doknic, Marina Nikolic Djurovic, Zvezdana Jemuovic, Vera Popovic, Milan Petakov

P2
Estimation of piezoelectric sensitivity at an ultrasound frequency in bovine cancellous bone
Presenter: Atsushi Hosokawa
Authors: Atsushi Hosokawa

P3
Explorative study of rats femorale bone with experimentally induced diabetes by resonant ultrasound spectroscopy
Presenter: Paulina Hernández
Authors: Paulina Alicia Irais Hernández-Becerra, Miguel Vargas-Luna, María Raquel Huerta-Franco, Isabel Delgadillo-Holtfort, Gabriel Herrera-Pérez, Rafael Vargas-Bernal, Xóchitl Sofía Ramírez-Gómez, Esmeralda Rodríguez-Miranda

P4
Fabrication of a self- assembling poly γ-glutamic acid based nanoparticle loaded triptolide for the treatment of rheumatoid arthritis
Presenter: Zhang Li
Authors: Zhang Li, Junli Chang, Yongjian Zhao, Hao Xu, Tengteng Wang, Qiang Li, Yongjun Wang, Qianqian Liang

P5
Microstructural decay in spinal cord injury
Presenter: Ali Ghasem-Zadeh
Authors: Ali Ghasem-Zadeh, Roger Zebaze, Andrew Nunn, Maya Panisset, Xiao-Fang Wang, Mary P. Galea, Ego Seeman

P6
Prevalence of sarcopenia in community dwelling German males and females 70+ using different recognized definitions. A BIA based approach
Presenter: Wolfgang Kemmler
Authors: Wolfgang Kemmler, Simon von Stengel, Klaus Engelke

P7
Sexual dimorphism in cortical bone morphology during pubertal growth in Chinese adolescents
Presenter: Elisa Man-Shan Tam
Authors: Ka-Yee Cheuk, Xiaofang Wang, Fiona Wai-Ping Yu, Elisa Man-Shan Tam, Bobby Kin-Wah Ng, Tsz Ping Lam, Ali Ghasem-Zahed, Roger Zebaze, Ego Seeman, Jack Chun-Yiu Cheng

P8
Skeletal site and location dependent elastic properties of human cortical bone measured by resonant ultrasound spectroscopy
Presenter: Xiran Cai
Authors: Xiran Cai, Laura Peralta, Quentin Vallet, Nicolas Bochud, Oliver Boughton, Richard Abel, Justin Cobb, Kay Raum, Jean-Gabriel Minonzio, Pascal Laugier, Quentin Grimal

P9
Ultrasonic computed tomography based on full-waveform inversion for bone quantitative imaging
Presenter: Simon Bernard
Authors: Simon Bernard, Vadim Monteiller, Dimitri Komatitsch, Philippe Lasaygues

P10
Ultrasonically induced electrical potentials in bovine cortical bone
Presenter: Taiki Makino
Authors: Taiki Makino, Koki Takano, Takafumi Kubota, Sayaka Matsukawa, Shinji Takayanagi, Takahiko Yanagitani, Mami Matsukawa

Timetable